Sleep deprivation selectively up-regulates an amygdala-hypothalamic circuit involved in food reward

www.biorxiv.org

"The results showed that whether sleep-deprived or not, participants were similarly hungry in the morning, and had similar levels of most hormones and blood sugar. However, when participants were sleep-deprived, they were willing to pay more for a food snack than when rested, and had higher levels in their blood of a substance called des-acyl ghrelin -- which is related to the "hunger hormone" ghrelin, though its function is not clear. The fMRI results showed that when sleep-deprived, participants had greater activity in the brain's amygdala (where food rewards are processed) when food images were shown, and a stronger link between the price participants would pay for food and activity in the hypothalamus (which is involved in regulating consumption). Interactions between these two regions increased compared with when participants had slept."

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